The Dreamer by Sheldon Siegel
Historically, the field of hematopoietic growth factor research began with the work of Carnot and Deflandre-in 1906 they suggested that the rate of erythropoiesis is regulated by a humoral factor found in the blood, namely, erythropoietin. From this comparatively early start, accelerating progress has been made in erythropoietin research, which demon- strates the general trends in this field of study. Erythropoietin was purified to homogeneity by 1977 (from enormous quantities of urine from aplastic anemia patients). Subsequently, the gene for erythropoietin has been cloned (1985), and massive quantities of this growth factor have been produced for clinical trials (late 1980s onward). Erythropoietin has become established as a pharmaceutical product of great value in the treatment of a number of diseases, most notably chronic renal failure. Once the ligand had been cloned, interest turned to the erythropoietin receptor, which was cloned in 1989. Since then, structure/ function studies have been performed on receptor mutants, cellular signaling events down- stream from the occupied receptor have been identified, and the specific producer cell types and molecular stimuli for erythropoietin production have been thoroughly investigated, as has the regulation of erythropoietin gene transcription. This schedule of events since the 1970s typifies that seen for a number of hematopoietic growth factors. Along the way, the hematopoietic growth factors have been recognized as members of the cytokine family of signaling molecules that are important in a number of different physiological and patholog- ical situations (see below).
Siegel, Sheldon: - Sheldon Siegel is the New York Times best-selling author of the critically acclaimed legal thriller series featuring San Francisco criminal defense attorneys Mike Daley and Rosie Fernandez, two of the most beloved characters in contemporary crime fiction. He is also the author of the thriller novel The Terrorist Next Door featuring Chicago homicide detectives David Gold and A.C. Battle. His books have been translated into a dozen languages and sold millions of copies worldwide. A native of Chicago, Sheldon earned his undergraduate degree from the University of Illinois in Champaign in 1980, and his law degree from the Boalt Hall School of Law at the University of California-Berkeley in 1983. He specializes in corporate and securities law with the San Francisco office of the international law firm of Sheppard, Mullin, Richter & Hampton LLP. Sheldon began writing his first book, SPECIAL CIRCUMSTANCES, on a laptop computer during his daily commute on the ferry from Marin County to San Francisco. A frequent speaker and sought-after teacher, Sheldon is a San Francisco Library Literary Laureate, a member of the national Board of Directors and the President of the Northern California chapter of the Mystery Writers of America, and an active member of the International Thriller Writers and Sisters in Crime. His work has been displayed at the Bancroft Library at the University of California at Berkeley, and he has been recognized as a Distinguished Alumnus of the University of Illinois and a Northern California Super Lawyer. Sheldon lives in the San Francisco area with his wife, Linda, and their twin sons, Alan and Stephen. He is a lifelong fan of the Chicago Bears, White Sox, Bulls and Blackhawks. He is currently working on his next novel. Sheldon welcomes your comments and feedback. Please email him at sheldon@sheldonsiegel.com. For more information on Sheldon, book signings, the making of his books, and more, please visit his website at www.sheldonsiegel.com.
| SKU | Unavailable |
| ISBN 13 | 9780999674772 |
| ISBN 10 | 0999674773 |
| Title | The Dreamer |
| Author | Sheldon Siegel |
| Series | Mike Daley Rosie Fernandez Legal Thriller |
| Condition | Unavailable |
| Binding Type | Paperback |
| Publisher | Sheldon M. Siegel, Inc. |
| Year published | 2020-03-04 |
| Number of pages | 342 |
| Cover note | Book picture is for illustrative purposes only, actual binding, cover or edition may vary. |
| Note | Unavailable |