Rune by Christopher Fowler

Rune by Christopher Fowler

Alzheimer's disease invades the brain from the inside. Unlike an abcess, a metas- tasis or an infarct, the disease follows specific tracks and avoids certain cortical areas while flourishing in others. Any observer is struck by the exquisite selectiv- ity of the lesions and could, indeed, conclude that Alzheimer's disease knows neuroanatomy. However, should the term disease be used to define this disor- der? Several genes, located on at least three different chromosomes, have been implicated in the disease. The ApoE4 genotype has been shown to be an impor- tant risk factor, but dementia pugilistica also suggests that environment can be involved in at least some aspects of the disorder. These data favor the now preva- lent view that Alzheimer's disease should instead be considered as a syndrome, and probably all of the contributors to this volume are ready to endorse this point of view. If Alzheimer's syndrome is the final common pathway to several pathoge- netic mechanisms, there should be an event at one point in the course of the spe- cific etiology that triggers a somewhat stereotypic diffusion process along some neural connections. Scientists who are fascinated by the way in which the ner- vous system has morphologically encoded its function after a long phylogenetic history are also fascinated by this pathological progression of Alzheimer's syn- drome.

Christopher Fowler was born in Greenwich, London. He is the multi award-winning author of thirty novels and ten short story collections, and the author of the Bryant & May mystery novels. His first bestseller was 'Roofworld'. Subsequent novels include 'Spanky', 'Disturbia', 'Psychoville' and 'Calabash'. His books have been optioned by Guillermo Del Toro ('Spanky') and Jude Law ('Psychoville'). He spent 25 years working in film. He recently wrote 'Red Gloves', 25 new stories of unease to mark his first 25 years of writing. His memoir 'Paperboy' won the Green Carnation Award, and is being followed by a new volume, 'Film Freak', in April 2013. Other new books include the dark comedy-thriller 'Plastic' and 'Invisible Ink: The Mysterious Case Of The Disappearing Authors'. He has written comedy and drama for BBC radio, including Radio One's first broadcast drama in 2005. He writes for the FT and the Independent on Sunday, Black Static magazine and many others. His graphic novel for DC Comics was the critically acclaimed 'Menz Insana'. His short story 'The Master Builder' became a feature film entitled 'Through The Eyes Of A Killer', starring Tippi Hedren and Marg Helgenberger. In the past year he has been nominated for 8 national book awards. He is the winner of the Edge Hill prize 2008 for 'Old Devil Moon', and the Last Laugh prize 2009 for 'The Victoria Vanishes'. Christopher has achieved several pathetic schoolboy fantasies, releasing a terrible Christmas pop single, becoming a male model, writing a stage show, posing as the villain in a Batman graphic novel, running a night club, appearing in the Pan Books of Horror, and standing in for James Bond. His short stories have appeared in Best British Mysteries, The Time Out Book Of London Short Stories, Dark Terrors, London Noir, Neon Lit, Cinema Macabre, the Mammoth Book of Horror and many others. After living in the USA and France he is now married and lives in King's Cross, London and Barcelona.

SKU	CIN0345364732G
ISBN 13	9780345364739
ISBN 10	0345364732
Title	Rune
Author	Christopher Fowler
Condition	Good
Binding Type	Hardback
Publisher	Ballantine Books
Year published	1991-01-09
Number of pages	340
Cover note	Book picture is for illustrative purposes only, actual binding, cover or edition may vary.
Note	This is a used book - there is no escaping the fact it has been read by someone else and it will show signs of wear and previous use. Overall we expect it to be in good condition, but if you are not entirely satisfied please get in touch with us