Through the Window
Through the Window
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Through the Window by Diane Fanning
The problem of unraveling two intertwined strands during the duplication of DNA was recognized shortly after the proposal of the DNA double helix structure in 1953. A group of enzymes called DNA topoisomerases solve this problem by breaking and rejoining DNA molecules in a controlled manner, thereby allowing strands to be passed through each other and thus untangled not just during DNA replication, but also during many other basic cellular processes. Because of their intimate involvement in the workings of the cell, topoisomerases are also the logical targets of many antibiotics (including Cipro) and anticancer agents. This book, written by James Wang, the discoverer of the first topoisomerase and a leader in the field since, presents ten chapters covering the historical backdrop of the DNA entanglement problem and the discovery of the DNA topoisomerases, how DNA topoisomerases perform their magic in DNA replication, transcription, genetic recombination and chromosome condensation, and how they are targets of therapeutic agents. The book should appeal to readers from undergraduates upwards with interests in the biological and clinical aspects of topoisomerase function, or in the mathematics and physics of topology.
Diane Fanning is the author of the Edgar Award finalist Written in Blood: A True Story of Murder and a Deadly 16-Year-Old Secret That Tore a Family Apart. Her other works of true crime include the best-selling Mommy's Little Girl, A Poisoned Passion, The Pastor's Wife, and Through the Window. She has been featured on 48 Hours, 20/20, Court TV and the Discovery Channel, and has been interviewed on dozens of radio stations coast to coast. Before becoming a nonfiction writer, Fanning worked in advertising, and she earned more than 70 Addy Awards. She lives in New Braunfels, Texas.
| SKU | Unavailable |
| ISBN 13 | 9780312985257 |
| ISBN 10 | 0312985258 |
| Title | Through the Window |
| Author | Diane Fanning |
| Condition | Unavailable |
| Binding Type | Paperback |
| Publisher | St. Martin's True Crime |
| Year published | 2003-04-14 |
| Number of pages | 288 |
| Cover note | Book picture is for illustrative purposes only, actual binding, cover or edition may vary. |
| Note | Unavailable |